Real-World Evidence on the Efficacy and Tolerability of Tramadol/Dexketoprofen (TRAM/DKP) Fixed-Dose Combination for the Management of Acute Non-surgical Pain in Asian Patients: A Multicentre Retrospective Case Series

Introduction: Multimodal analgesia is key in the effective management of acute pain. Previous clinical trials have demonstrated good results with use a fixed-dose combination (FDC) tramadol 75 mg and dexketoprofen 25 (TRAM/DKP) pain management. However, there dearth real-world evidence on efficacy safety this non-surgical pain, especially among Asian patients. The case series reported herein investigates experiences physicians patients TRAM/DKP FDC Methods: Data were collected retrospectively 11 across multiple hospitals who had received short course for orthopaedic non-orthopaedic baseline characteristics, medical history, treatment regimen, outcomes, patient satisfaction compiled shared at peer-to-peer expert meeting October 2022. Results: All experienced reduction intensity very satisfied management, mean score 4.3/5. Five (range: 63-74 years) mild adverse events, including nausea, vomiting, dizziness, which resolved no need additional majority cases. No serious events recorded. Conclusion: achieved control FDC. regimen was well tolerated, high levels indicating that an choice